Showering 3 hours after application of ANDRODERM increased Cavg by 0.5% and decreased Cmax by 0.4% respectively, as compared to not showering. Upon removal of the ANDRODERM systems, serum testosterone concentrations decrease with an apparent half-life of approximately 70 minutes. Inactivation of testosterone occurs primarily in the liver. Visit your care team for regular checks on your progress. Some items may interact with your medicine. Also tell them if you smoke, drink alcohol, or use illegal drugs. Do not use double or extra doses. If the patch becomes loose, simply smooth it down again around the edges. Do not share this medicine with others. Be sure to read this information carefully each time. Table 3 summarizes testosterone Cavg categories by treatment. After a total of 28 days of therapy, 34 of the 35 subjects (97%) had serum testosterone Cavg within the normal range during the dosing period, with the lower bound of the 95% confidence interval for this estimate being 85% (Table 3). Once daily for 14 days, and then were titrated up to 6 mg/day or down to 2 mg/day according to a morning serum testosterone concentration obtained at 6 a.m. Do not apply topical testosterone to other areas not recommended in the product instructions, such as your stomach, penis, or scrotum. Your pharmacist can tell you all of the ingredients in the specific topical testosterone products they stock. Misusing topical testosterone can lead to serious side effects, such as heart problems or mental health problems. Stop using topical testosterone and get emergency help if you have any of the following signs of blood clots. Common side effects include skin reactions where the medicine is applied, changes in certain lab test results, headache, high blood pressure, and mood swings. Each patch is individually pouched and supplied in cartons of 5 and 301.1 Not all pack sizes and strengths may be available. Apply to skin immediately upon removal from the protective pouch. The drug reservoir may be burst by excessive heat or pressure. Incompatibilities were either not assessed or not identified as part of the registration of this medicine. The effects of this medicine on a person's ability to drive and use machines were not assessed as part of its registration. Androderm is indicated for testosterone replacement therapy for confirmed testosterone deficiency in males. The structure of testosterone (17β-hydroxyandrost-4-en-3-one) is given below.
